The importance of space information in an efficient investigation of fluid-conducting lithosphere structures is demonstrated with the use of some regions (the Black Sea, Western Siberia) as an example. These lithosphere structures play a large part in the development of numerous geological, geomorphological, and geophysical processes (e. g., the location of mineral deposits, development of erosion processes, formation of certain relief formations and geopathogenous zones, etc. For the space information to be used efficiently in the solution of most important practical and scientific problems, the techniques of its application need to be developed at the level of fundamental and applied investigations.