Exogenous melatonin influence on lipid and amino acid composition of bone’s organic matrix

1Berezovskii, VA, 1Litovka, IG, 2Veselskii, SP, 1Zamorska, TM, 1Yanko, RV
1Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
2P. Bogach Institute of Physiology of the Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Kosm. nauka tehnol. 2012, 18 ;(3):78–82
Publication Language: Ukrainian
We consider the influence of exogenous melatonin on lipid and amino acid composition of the organic matrix for 11-and 15-month Wistar male-rats. Our study shows a significant increase in the concentration of total phospholipids for 11- and 15-month animals by 19 % and 26 %, respectively. The exogenous melatonin in a dose of 1 mg/kg b. w. significantly reduces the concentration of cystine (by 35 %), ornithine (by 59 %), and lysine (by 33 %) in the bone tissue of 11-month rats. For the 15-month rats, a reliable decrease in the concentration of serine and aspartic acid by 29 % is observed. We believe that exogenous melatonin has an indirect effect on bone metabolism by increasing polar lipids and by reducing free amino acids. This points to the activation of bone remodeling processes and to collagen synthesis intensification
Keywords: bone metabolism, lipid and amino acid composition, melatonin
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