Features of plant cell cycle regulation under altered gravity conditions
|1Artemenko, OA |
1Institute of Botany of the National Academy of Science of Ukraine, Kyiv, Ukraine
|Kosm. nauka tehnol. 2015, 21 ;(5):108–112|
|Publication Language: Ukrainian|
Cyclins and cyclin-dependent kinases (CDK) are main regulators of the cell cycle of eukaryotes. It’s assumes a significant change of their level in cells under microgravity conditions and by other physical factors actions. The clinorotation use enables to determine the influence of gravity on the simulated events in a cell during the cell cycle — exit from the state of quiet stage and propagation through presynthetic phase (G1) and DNA synthesis phase (S) of the cell cycle. For the clinorotation effect study on a cell proliferation activity is the necessary study of molecular mechanisms of the cell cycle regulation and development of plants under altered gravity conditions. The activity of cyclin D, which is responsible for the events of the cell cycle in presynthetic phase can be controlled by the action of endogenous as well as exogenous factors, but clinorotation is one of the factors that influence on genes expression that regulate the cell cycle. This data can be used as a model for a further research on cyclin — CDK complex for study molecular mechanisms of regulation of growth and proliferation. In this investigation we tried to summarize and analyze both bibliographic sources and our own data as for the main regulators of the cell cycle in altered gravity conditions.
|Keywords: cell cycle, clinorotation, cyclin-depending kinases, cyclins, gravysensitive, plant|
1. Artemenko O.A. Modern conceptions about regulation of cell cycle in plants. Ukrainian botanical journal. 58(4), 415 —421 (2001) [in Ukrainian].
2. Artemenko O.A. Expression of d1- and d3-cyclin genes in pea (Pisum sativum L.) root meristem under clinorotation. Cytology and Genetics. 40(2), 36 —41 (2006) [in Ukrainian].
3. Artemenko O.A. Cell cycle regulators in Arabidopsis thaliana (brassicaceae) transgenic plants under clinorotation. Cyclin-depending kinases. Ukrainian botanical journal. 71(5), 620 —625 (2014) [in Ukrainian].
4. Aarrouf J., Schoevaert D., Maldiney R., Perbal G. Changes in hormonal balance and meristematic activity in primary root tips on the slowly rotating clinostat and their effect on the development of the rapeseed root system. Physiol. Plant. 105, P. 708 —718 (1999).
5. Fuster Jose J., Fernandez Patricia, Gonzalez-Navarro Herminia, Silvestre Carlos, et al. Control of cell proliferation in atherosclerosis: insights from animal models and human studies. Cardiovasc. Res.doi:10.1093/cvr/cvp363. First published online: November 9,2009.
6. Healy J.M., Menges M., Doonan J.H., Murray J.A. The Arabidopsis D-type cyclins CycD2 and CycD3 both interact in vivo with the PSTAIRE cyclin-dependent kinase Cdc2a but are differentially controlled. J.Biol.Chem. 276, P.7041 —7047 (2001).
7. Herranz R., Medina F.J. Cell proliferation and plant development under novel altered gravity environments. Plant Biol.(Stuttg). 16(1), P. 23 —30 (2014).
8. Inagaki S., Umeda M. Cell-cycle control and plant development. Int.Rev.Cell Mol.Biol. 291, P. 227 —261 (2011).
9. Kordyum E.L. Biology of plant cell microgravity and under clinostating. Int.Rev.Cytol. 171, P.1 —72 (1997).
10. Medina F., Herranz R. Microgravity environment uncouples cell growth and cell proliferation in root meristematic cells. The mediator role of auxin. Plant Signal Behav. 5(1), P. 176 —179 (2010).
11. Merkys A.J., Laurinavicius R.S. Plant growth in space. Fundamentals of Space Biology / Eds M.Asashima, G.M.Malacinski. P.69—83 (Jap. Sci. Soc. Press, Tokyo; Springer Verlag, Berlin, 1990).
12. Mews M., Moore R. Cyclin/ Cdk complexes: their involvement in cell cycle progression and mitotic division. Protoplasma. 216(3-4), P.119—142 (2001).
13. Morgan D.O. The cell cycle: principles of control. 297 p. (New Science Press, 2007).
14. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13(12), P.1501 —1512 (1999).
15. Van den Heuvel S., Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Sci. 262, P.2050 —2054 (1994).