The effects of neutron irradiation on the rate of gaseous exchange and activity of the key antioxidant enzymes in the liver of mice

1Muradian, Kh.K, 1Utko, NA, 1Badova, TA, 1Bezrukov, VV, 1Butenko, GM, 1Pishel, IN, 1Rodnichenko, AE, 1Sytnik, LN, 1Ustimenko, AN, 2Zheltonozhskii, VA, 2Sadovnikov, LV, 3Tarasov, GG
1State Institution "D.F.Chebotarov Institute of Gerontology of the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine
2Institute for Nuclear Research of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
3V.Ye. Lashkaryov Institute of Semiconductor Physics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Kosm. nauka tehnol. 2003, 9 ;(2-3):090-098
Publication Language: Russian
An attempt is made to develop a ground-based model of the irradiation by so-called intermediate neutrons which is specific to the secondary radiation in spacecrafts. For this purpose we used a 252Cf98-containing source for which the neutron spectrum formed by hydrogen-containing materials has the mode in the range from 1 to 5 MeV. A dose-dependent increase of the oxygen consumption (Vo2, r = 0.48, P< 0.001)) and of carbon dioxide exhalation (Vco2 г = 0.59, P< 0.001) rates was found within 22–24 hours after irradiation of mice by doses of 2 Gy, 4 Gy, and 6 Gy. Positive correlations of the liver catalase activity with Vo2 (r = 0.66, P < 0.001) and Vco2 (r = 0.63, P < 0.001) for the group of intact mice are absent for the group of animals irradiated by a dose of 2 Gy. Our analysis with the use of three-dimensional non-linear plotting is indicative of quantitative and qualitative differences of interrelations between the pro- and antioxidant variables under discussion.
Keywords: antioxidant, liver of mice, neutron irradiation
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