Space experiment «Biosorbent»: development of the «Microcolumn» apparatus and organization of experiments on biospecific sorption in weightlessness conditions aboard the Russian Segment of the International Space Station

Heading: 
Space Life Sciences
1Kartel, MT, 2Bakalinskaya, ON
1Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, Kyiv, Ukraine
2Institute for Sorption and Problems of Endoecology of National Academy of Science of Ukraine, Kyiv
Kosm. nauka tehnol. 2010, 16 ;(4):66-74
https://doi.org/10.15407/knit2010.04.066
Publication Language: Russian
Abstract: 
The physical-chemical basics for carrying out affine sorption in the microcolumn experiment are developed and the choice of adsorbents and biological liquids is performed. The advisability and necessity of space experiment «Biosorbent» are proved. The device for the space experiment is developed. The modernized variant of the device UMK-2 which is suited to the requirements of the Russian standards for the scientific instrumentation operating on the Russian segment of the International Space Station is proposed and taken to be made
Keywords: biospecific sorption, space experiment, weightlessness
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References: 
1. Strelko V. V., Sukharenko N. V., Mykhailovskyi S. V., et al. Immunosorbent for blood purification and method for obtaining thereof. A. s. 1226785 SSSR; published 22.12.1985 [in Russian].
2. Bakalinskaya O. N., Sukharenko N. V., Zherebtsova E. N. A method for producing an immunosorbent. A. s. 1637079 SSSR; published 22.11.1990 [in Russian].
3. Bakalinskaya O. N., Kartel N. T., Strelko V. V. Carbon sorbents are a new type of carrier for the immobilization of biologically active substances: Preprint ISPJe 92/01, 60 p. (Kiev, 1992) [in Russian].
4. Bakalinskaya O. N., Kartel N. T., Strelko V. V. Carbon sorbents with biospecific activity. In: The mechanism of influence on the chemistry of hetero active carbons. Selective adsorption and catalysis on active carbons and inorganic ion exchangers, Ed.by V.V. Strelko, 65—87 (Naukova dumka, Kyiv, 2008) [in Russian].
5. Bakalinskaya O. N., Koval N. M., Karabun P. M., et al. Nonspecific hemosorbents to remove antibodies to insulin. Efferent Therapy, 3 (1), 21—25 (1997) [in Russian].
6. Bakalinskaya O. N., Koval N. M., Kartel N. T. Biospecific adsorbents for the removal of free hemoglobin. Efferent Therapy, 5 (3), 33—37 (1999) [in Russian].
7. Bakalinskaya O. N., Koval N. M., Kartel N. T. Preparation of carbon sorbents with nonspecific activity. Efferent Therapy, 9 (2), 16—22 (2003) [in Russian].
8. Bakalinskaya O. N., Koval N. M., Kartel N. T. Application of carbon sorbents with biospecific activity in extracorporeal detoxification. Efferent Therapy, 10 (1), 21—26 (2004). [in Russian].
9. Bakalinskaya O. N., Koval N. M., Kartel N. T. Synthesis and investigation of carbon biospesific hemosorbents on the basis of carbons of SCN,CSC and KAU type. Efferent Therapy, 11 (1), 33—39 (2005) [in Russian].
10. Bakalinskaya O. N., Sukharenko N. V., Strelko V. V., et al. Sorption properties of carbon hemosorbents with immobilized proteins. Ukr. khim. zhurn., 55 (12), 1273—1276 (1989) [in Russian].
11. Gorchakov V. D., Sergienko V. I., Vladimirov V. G. Selective Hemosorbents, 224 p. (Meditsina, Moscow, 1989) [in Russian].
12. Grigoriev A. I., Egorov A. D. Phenomenology and mechanisms of changes in the basic functions of the human body in weightlessness. Kosm. Biol. Aviakosm. Med., 22 (6), 4—17 (1988) [in Russian].
13. Kartel N. T. Carbon hemosorbents based on synthetic active carbons: Extended abstract of Doctor’s thesis, 32 p. (Kiev, 1989) [in Russian].
14. Kartel N. T. Possibilities of therapeutic action of medical sorbents on the basis of the activated coals. Efferent Therapy, 1 (4), 11—18 (1995) [in Russian].
15. Kartel N. T., Bakalinskaya O. N., Koval N. M., et al. Experiment "Biosorbent" as a model of hemosorption and sorption of biopreparations under microgravity conditions. 4th Ukrainian Conference on Space Research: Abstracts, Ponizovka, Crimea, September 19–26, 2004, P. 204 (2004) [in Russian].
16. Koval N. M., Bakalinskaya O. N., Medvedev S. L., et al. Properties of hemosorbents SKN with grafted amino acids and amines. Ukr. khim. zhurn., 57 (11), 1132—1135 (1991) [in Russian].
17. Lopatkin N. A., Lopukhin Yu. M. Efferent Methods in Medicine, 352 p. (Meditsina, Moscow, 1989) [in Russian].
18. Lopukhin Yu. M., Molodenkov M. N. Hemosorption, 302 p. (Meditsina, Moscow, 1978) [in Russian].
19. Nikolaev V. G. Method of hemocarboperfusion in experiment and clinic, 360 p. (Naukova Dumka, Kyiv, 1984) [in Russian].
20. Nikolaev V. G., Strelko V. V. Hemosorption on Activated Carbons, 288 p. (Nauk. Dumka, Kiev, 1979) [in Russian].
21. Panchenkov R. T., Vyrenkov Yu. E., Yarema I. V., Urtayev B. M. Limosorption, 240 p. (Meditsina, Moscow, 1982) [in Russian].
22. Strelko V. V., Kartel M. T., Puzii O. M., et al. Synthetic carbonic material of spherical granulation for sorption of substances from solutions and method of its obtaining. Pat. 1836138 SSSR; published 13.10.1992, Bull. No. 31. (Pat. 3396 Ukraine; published 15.06.1994, Bull. No. 6-1) [in Russian].
23. Bakalinska O. M., Koval N. M., Kartel M. T., et al. Sorbent for extraction of free haemoglobin from biological liquids. Pat. 255 Ukraine; published 15.01.1993, Bull. No. 1. (Pat. 2035995 RF; published 27.05.1995, Bull. No. 15) [in Ukrainian].
24. Bakalinska O. M., Koval N. M., Karabun P. M., et al. Sorbent for producing the insulin antibodies from biological liquids and method of its producing. Pat. 19017 Ukraine, MKI B01J 20/20, C12N 11/00; published 25.12.1997, Bull. No. 6 [in Ukrainian].
25. Koval N. M., Bakalinska O. M., Kartel M. T., Strelko V. V. Method of immobilization on a carbon-containing carrier of amine-containing biologically active compounds. Pat. 10481 Ukraine; published 12.11.1999, Bull. No. 7 [in Ukrainian].
26. Popova I. A., Morukov B. V., Arzamazov G. S., et al. Metabolic characteristics during 120-day head-down tilt hypokinesia. Kosm. Biol. Aviakosm. Med., 22 (2), 40—45 (1988) [in Russian].
27. Strelko V. V., Kartel N. T., Mikhalovsky S. V., et al. Carbon sorbents as a basis for the creation of biospecific materials . Sorption methods of detoxification and immunocorrection in medicine: Tez. dokl. pervoj vsesojuz. konf., Kharkov, June 28—30, 1982, P. 320 (Kharkov, 1982) [in Russian].
28. Strelko V. V., Mikhalovsky S. V., Sukharenko N. V., et al. On the possibility of creating biospecific materials based on biocompatible carbon matrices. Dokl. AN SSSR, 274 (5), 1236—1238 (1984) [in Russian].

29. Turkova J. Affinity Chromatography. Methods, 278 p. (Mir, Moscow, 1988) [in Russian].