Activity of interferon-dependent 2', 5'-oligoadenylate synthetase in rat lymphoid cells under transformed environment conditions

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Space Life Sciences
1Ostapchenko, LI, 1Mikhailik, IV, 1Prokopova, KV
1Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Kosm. nauka tehnol. 2007, 13 ;(2):069-074
https://doi.org/10.15407/knit2007.02.069
Publication Language: Ukrainian
Abstract: 
It is detected that interferon-dependent 2',5'-oligoadenylate synthetase is a sensitive index of immunocompetent cells functional state under transformed environment conditions. Microgravi-tation and ionising radiation induce increase of investigated enzyme activity in rat lymphocytes, which can be a result of lymphoid cells compensatory mechanisms starting in response to stress factors action. Administration of interferon inductors permits one to stimulate the 2',5'-oligoadenylate synthetase, which enables one to correct pathological changes in the cells and to intensify adaptative reactions of immune system.
Keywords: interferon inductors, lymphoid cells, stress factors
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