Influence of melatonin on processes of the bone tissue physiological regeneration of young and adult rats
|1Berezovskii, VA, 1Litovka, IG, 1Kostjuchenko, AS, 1Yanko, RV |
1Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
|Kosm. nauka tehnol. 2008, 14 ;(3):075-081|
|Publication Language: Ukrainian|
We studied the influence of 28-day administration of exogenous melatonin in a dose of 1 mg/kg on the processes of bone tissue physiological remodeling of 3- and 9-monthly rats-males. It is discovered that an initial concentration of melatonin is higher in adult rats, than in 3-monthly rats. We showed a significant increase of 50 % and 25.6 % in serum melatonin concentration for youths and adult experimental rats, respectively, a significant enhancement of alkaline phosphatase activity in bone tissue for both of the experimental groups of animals, its decline in the serum of 9-monthly rats and the tendency for a decline in 3-monthly ones. The increase of endogenous level of hormone was accompanied by a significant enhancement of acid phosphatase activity by a factor of 1.6 and 1.3 as well as of glicozamino-glikans serum concentrations by a factor of 3.1 and 1.4 for 3-and 9-monthly rats, respectively. IGF-I gene expression level for the animals in both of the groups under invesigation had a tendency for an increase. The conclusion is made that administration of melatonin in a dose of 1 mg/kg intensifies considerably the process of bone tissue physiological remodeling both for young and for adult rats.
|Keywords: endogenous level, glicozamino-glikans, phosphatase|
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