Artificial gravity and glutamatergic transmission in cerebral hemispheres
|1Borisova, TA, 1Krisanova, NV, 2Himmelreich, NH |
1Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Kyiv, Ukraine
2O.V. Palladin Institute of Biochemistry of the NAS of Ukraine, Kyiv, Ukraine
|Kosm. nauka tehnol. 2002, 8 ;(5-6):062-065|
|Publication Language: Russian|
We investigated the effect of hypergravity stress (created by centrifugation of rats at lOg over the course of 1 hour) on the L- [14 С] glutamate release from isolated rat brain cerebral hemispheres nerve terminals. It is shown that the hypergravity stress exerted a different influence on the Ca2+-dependent and the Ca2++-independent components of L- [14 С] glutamate release. The Ca2+-dependent L- [14 С] glutamate release stimulated with a standard stimulus, 35 mM KC1, was decreased by more than one half as a result of the hypergravity stress and was equal to 14.4±0.7 % for control animals and 6.2±1.9 % for animals exposed to hypergravity (P ≤ 0.05). At the same time we observed no statistically significant difference in the Ca 2+-independent component of L- [14 С] glutamate release. Our data allows us to make a suggestion that the redistribution of the neurotransmitter between cytosolic and vesicular pools in nerve terminals occurs in altered gravity conditions.
|Keywords: brain, glutamate, hypergravity stress|
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