Strengthening osteoclast activity in rats under conditions of underlying load deficiency

1Polkovenko, OV
1I.I. Schmalhausen Institute of Zoology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Kosm. nauka tehnol. 2002, 8 ;(Supplement2):463-468
Publication Language: Russian
Abstract: 
The features of resorption in the spongy substance of the femurs of rats were studied under conditions of simulated hypokinesia (hanging model, 3-4 weeks long), as well as in space experiments conducted on board the American station SLS-2 (flight duration - 2 weeks ). It was revealed that under conditions of reduced supporting load, bone resorption occurs due to increased activity of osteoclasts. The appearance of "giant osteoclasts" with increased functional activity has been established. Under weightless conditions, the number of "giant osteoclasts" is greater than with simulated hypokinesia. For control animals, the presence of such cells is uncharacteristic.
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